Patient Presentation: A 23-year-old obese female was diagnosed with idiopathic intracranial hypertension (IIH) and referred to neurosurgery for ventriculoperitoneal shunt. A baseline ocular examination was performed prior to the procedure.
On examination, vision was 20/200 in the right eye, and 20/40 in the left eye. There was a right relative afferent pupillary defect. Slit lamp examination was normal.
A dilated fundus examination was performed demonstrating the following:
Contributor: Korolos Sawires
Patient Presentation: A 45-year old female was referred to a neuro-ophthalmology clinic for concern of an optic nerve lesion in the right eye. The patient noted that she was told there was something "atypical" with her optic nerve during an eye exam as a teenager. She is asymptomatic. Her past medical history revealed asthma with no significant family history.
Visual acuity was 20/20 OD and 20/20 OS with normal pupil size and no RAPD. Humphrey 24-2 SITA fast visual fields and a fundus photograph of the right eye are shown below:
Question 1: What is the main finding of the fundus photo and HVF testing above?
Next, an OCT RNFL and GCA were performed and are shown below:
An OCT HD cross of the right optic nerve was performed and is shown below:
Question 2: What is the main finding of this OCT?
Question 3: What is the most likely diagnosis?
Question 4: What clinical findings is Tuberous sclerosis complex commonly associated with?
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Northrup H, Krueger DA, Northrup H, Krueger DA, Roberds S, Smith K, et al. Tuberous Sclerosis Complex Diagnostic Criteria Update: Recommendations of the 2012 International Tuberous Sclerosis Complex Consensus Conference. Pediatric Neurology. 2013;49(4):243-54.
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Soliman W, Larsen M, Sander B, Wegener M, Milea D. Optical coherence tomography of astrocytic hamartomas in tuberous sclerosis. Acta Ophthalmol Scand. 2007 Jun;85(4):454-5. doi: 10.1111/j.1600-0420.2006.00795.x. PMID: 17559471.
To identify OCT features of astrocytic hamartomas and be able to differentiate between different neuro-ophthalmic pathologies.
To identify the systemic disease that is associated with astrocytic hamartomas.